Nifedipine Tablets product summary

Please use it under the guidance of a doctor

[drug name]

Generic name: Nifedipine Tablets

English Name: Tablets Nifedipine

Chinese Pinyin: Pian xiaobendiping

[properties] this product is coated, after the coating was removed yellow.

[indications]

1 angina pectoris: variant angina pectoris; unstable angina pectoris; chronic stable angina pectoris.

2 high blood pressure (alone or in combination with other antihypertensive drugs).

[Specification] 10mg 5mg

[usage and dosage]

1. Nifedipine dose should be considered the tolerance of patients and will gradually adjust the control on angina pectoris. An overdose of nifedipine can lead to hypotension.

2. Starting from a small dose of taking, generally starting dose of 10mg / (1), 3 times a day orally; commonly used maintenance dose of oral 10~20mg/ (1 ~ 2), 3 times a day. Part of patients with significant coronary artery spasm, available to 20~30mg/ (2-3 tablets), a day 3 to 4 times. Maximum dose should not be more than 120mg / day (12 pieces). If the disease is urgent, chew or tongue taking 10mg / (1 piece), according to the patient's response to drugs, decided once again to the drug.

3. Usually adjust the dose must be between 7 and 14 days. If patients with obvious symptoms, condition of emergency, the dosage adjustment period can be shortened. According to patient response to the drug, the frequency of attacks and tongue with the dose of nitroglycerin, within 3 days will the amount of nifedipine from 10-20 (1 ~ 2), transferred to 30mg / time sheet (3), a day 3 times.

4 hospitalized patients under strict monitoring, according to the control of angina or ischemic arrhythmia, every 4~6 hours to increase 1 times, each time 10mg (1).

[adverse reactions]

There are 1 common peripheral edema after medication (peripheral edema associated with the dose, taking 60mg/, the incidence rate was 4%, taking 120mg/ for 12.5%); dizzy; headache; nausea; fatigue and flushing (10%). A transient hypotension (5%), do not need to stop (a hypotension associated with the dose, dose in <60mg/ days when the incidence rate was 2%, and 120mg/, the incidence rate of 5%). Individual patients with angina, and hypotension may still visible. Palpitation; nasal obstruction; chest; shortness of breath; constipation; diarrhea; gastrointestinal spasm; abdominal distension; skeletal muscle inflammation; joint stiffness muscle spasm;; mental stress; neuroticism; tremor; sleep disorder; blurred vision; imbalance (2%). (0.5%), syncope reduction or in combination with other anti anginal drugs will no longer occur.

2. Rare anemia; leukopenia; platelet reduction; purpura; allergic hepatitis; gingival hyperplasia; depression; bias; blood drug concentration peak instantaneous blindness; erythromelalgia; anti nuclear antibody positive joint inflammation <0.5%.

3 possible serious adverse reactions: myocardial infarction and congestive heart failure rate of 4%; the incidence of pulmonary edema 2%; the incidence of arrhythmias and conduction block is less than 0.5%.

4 this product allergy can appear allergic hepatitis, skin rash, even peeling off sex dermatitis and so on.

[taboo] to disable nifedipine allergy.

[note] 

1. Hypotension. The vast majority of patients after taking nifedipine only mild hypotension, individual patients appeared the symptoms of severe hypotension. This reaction occurs in a dose adjustment or increase the amount of, especially when beta blockers are combined. During this period were monitored for blood pressure, especially combined with other antihypertensive drugs.

2. Fentanyl anesthesia patients undergoing coronary artery bypass grafting (or other surgery), separate administration of nifedipine or treatment with beta blockers can lead to severe hypotension, such as conditions permit should at least stop drug 36 hours.

3. Angina pectoris and / or myocardial infarction. Very few patients, especially in patients with severe coronary artery stenosis and during taking nifedipine or add a quantity, Buck appeared reflection sex excitement and speed up the heart rate, angina or myocardial infarction occurred rate increased.

4. Peripheral edema and 10% in patients with mild to moderate outside peripheral edema, and arterial expansion. The edema is primary in the lower extremities and diuretic therapy is available. For patients with congestive heart failure, need to differentiate edema is due to left ventricular function further deterioration caused by.

5. Beta blockers "anti jump" symptoms. Suddenly stopping beta receptor blocker enabled nifedipine, even as angina should be gradually decreasing the dosage of the former the. 3.

6. Congestive heart failure. A few of them receive beta blockers in patients started taking nifedipine can occur after heart failure, this product when I can with alkaline phosphatase by application of interference in the diagnosis of severe aortic stenosis patients at greater risk., creatine phosphokinase, lactate dehydrogenase, aspartate amino acid shift enzyme and alanine amino transferase rise, generally no symptoms, but there have been reports of cholestasis and jaundice; platelet aggregation degree is reduced, the prolongation of the bleeding time; the direct Coombs test positive with / without hemolytic anemia.

8. Liver and kidney function is not complete, are taking beta blockers who should be used with caution, dosage should be started from a young age, to prevent induced or aggravated hypotension, increased angina, heart failure, the incidence of myocardial infarction or even. Patients with chronic renal failure (CRF) application occasional reversible blood urea nitrogen and creatinine rises this product, and nifedipine is not clear enough.

9 long-term administration should not be stopped, in order to avoid the occurrence of withdrawal syndrome and rebound phenomenon.

[pregnant women and breastfeeding women medication]

1 clinical research data in detail. Clinically, nifedipine for hypertension in pregnant women.

2 nifedipine can be secreted into the milk, lactating women should stop or stop breastfeeding.

The trial was not carried out and there was no reliable references.

[old] Drug nifedipine in elderly half-life and the application note to adjust the dose.

[drug overdose]

No enough research data. Existing literatures show that increase in the dose may enable peripheral vascular excessive expansion, cause or worsen hypotension. Drug overdose clinical hypotension patients, should be timely and cardiovascular support treatment, including cardiopulmonary monitoring, leg elevation, pay attention to circulating blood volume and urine volume. If there are no taboos, available vasoconstrictor (norepinephrine) recovery of vascular tone and blood pressure. Liver function damage in patients with drug clearance time prolonged. Hemodialysis can not remove nifedipine.

[storage] light shading, sealed preservation.

[packing] plastic bottle packaging, 100 / bottle.

[Effective] 24 months

[executive standard] < Chinese Pharmacopoeia >2015 version two

[approval] 5mg Zhunzi H32024487

        10mg national drug standard word H32024487